Prescription Medication — Information Only

Bupropion

An antidepressant medication also licensed for smoking cessation, which reduces withdrawal symptoms and cravings.

What it is

Bupropion is a prescription medication originally used as an antidepressant and also licensed for smoking cessation in many countries.

How it works

It acts on dopamine and noradrenaline systems in the brain, reducing nicotine withdrawal symptoms and cravings. It is typically started before the quit date.

Evidence and effectiveness

Cochrane reviews find bupropion roughly doubles quit success compared with placebo, though it appears somewhat less effective than varenicline and combination NRT in network meta-analyses.

Evidence strength: Strong

Reported community experiences

Community reports mention reduced cravings and withdrawal, with some reporting dry mouth, insomnia and mood changes. Community records are being compiled in the Experience Database.

Common considerations

  • Prescription-only: suitability must be assessed by a healthcare professional
  • Contraindicated in certain conditions (e.g. seizure disorders); discuss medical history with the prescriber
  • Report mood changes promptly to the prescriber

Limitations

Prescription medication: this page is information only. Individual suitability, dosing and risks are matters for a prescribing professional.

Questions to ask a healthcare professional

  • Is this medication appropriate for my medical history and current conditions?
  • What dose and duration would you recommend for me, and how should I take it?
  • What side effects should I expect and which ones mean I should contact you?
  • Does it interact with any of my other medications?
  • What happens if I smoke while using it?
  • How long should I continue it after quitting?

This page is information only. It does not recommend this medication for any individual, does not suggest doses, and does not replace professional medical advice.

Source: Cochrane reviews find bupropion roughly doubles quit success compared with placebo, though it appears somewhat less effective than varenicline and combination NRT in network meta-analyses. Community reports are de-identified and are not scientific evidence.