Prescription Medication — Information Only
Varenicline
A prescription medication that reduces both craving and the rewarding effect of nicotine. Among the most effective single medications.
What it is
Varenicline is a prescription medicine (sold under brand names such as Chantix in some markets) that partially stimulates nicotine receptors in the brain.
How it works
It binds to nicotinic receptors, reducing withdrawal symptoms and blocking much of the pleasure from smoking if a person does smoke, which weakens the reward loop.
Evidence and effectiveness
Cochrane reviews and network meta-analyses rank varenicline among the most effective single medications for quitting, roughly doubling or more the odds of success versus placebo in clinical trials.
Evidence strength: Strong
Reported community experiences
Community reports describe reduced enjoyment of cigarettes and reduced craving, alongside reports of nausea, unusual dreams and mood changes. Community records are being compiled in the Experience Database.
Common considerations
- It requires a prescription: discuss suitability, dosing and side effects with a healthcare professional
- Report any significant mood changes to the prescriber promptly
- Combine with behavioral support for best results
Limitations
This is a prescription medication. This page provides information only; it cannot determine whether varenicline is appropriate for any individual. Contraindications and warnings must be discussed with a prescribing professional.
Questions to ask a healthcare professional
- Is this medication appropriate for my medical history and current conditions?
- What dose and duration would you recommend for me, and how should I take it?
- What side effects should I expect and which ones mean I should contact you?
- Does it interact with any of my other medications?
- What happens if I smoke while using it?
- How long should I continue it after quitting?
This page is information only. It does not recommend this medication for any individual, does not suggest doses, and does not replace professional medical advice.
Source: Cochrane reviews and network meta-analyses rank varenicline among the most effective single medications for quitting, roughly doubling or more the odds of success versus placebo in clinical trials. Community reports are de-identified and are not scientific evidence.