Prescription Medication
Bupropion
An antidepressant medication also licensed for smoking cessation, which reduces withdrawal symptoms and cravings.
What it is
Bupropion is a prescription medication originally used as an antidepressant and also licensed for smoking cessation in many countries.
How it works
It acts on dopamine and noradrenaline systems in the brain, reducing nicotine withdrawal symptoms and cravings. It is typically started before the quit date.
Evidence
Cochrane reviews find bupropion roughly doubles quit success compared with placebo, though it appears somewhat less effective than varenicline and combination NRT in network meta-analyses.
Evidence strength: Strong
Reported community experiences
Community reports mention reduced cravings and withdrawal, with some reporting dry mouth, insomnia and mood changes. Community records are being compiled in the Experience Database.
Practical considerations
- Prescription-only: suitability must be assessed by a healthcare professional
- Contraindicated in certain conditions (e.g. seizure disorders); discuss medical history with the prescriber
- Report mood changes promptly to the prescriber
Limitations
Prescription medication: this page is information only. Individual suitability, dosing and risks are matters for a prescribing professional.
This method involves a medication. This page provides information only — it is not a prescription, dosing advice or a substitute for professional medical judgment. See the medication evidence page and talk to a healthcare professional.
Community-reported experiences are de-identified individual accounts and do not constitute scientific evidence or medical advice.